Ciglitazone
Cat. No.：YN290809
| 产品名称: | Ciglitazone |
| CAS No.: | 74772-77-3 |
| Chemical Name: | 5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | 环格列酮; ADD-3878; U-63287 |
| 分子量: | 333.4 |
| 分子式: | C18H23NO3S |
| SMILES: | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCCCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ciglitazone 是一种有效的选择性PPARγ激动剂 (EC50=3 μM)。Ciglitazone 抑制 th17 细胞的增殖和分化。Ciglitazone 是一种口服降糖剂，在肥胖高血糖动物模型中具有活性。Ciglitazone 诱导负鼠肾上皮细胞凋亡 (apoptosis)，同时激活p38 MAPK和凋亡诱导因子 (AIF) 的核转位。 |
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Willson, T.M., Cobb, J.E., Cowan, D.J., et al.The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinedionesJ. Med. Chem.39(3),665-668(1996)
