HC-Toxin
Cat. No.：YN290811
| 产品名称: | HC-Toxin |
| CAS No.: | 83209-65-8 |
| Chemical Name: | (6R,9S,14aR)-3,6R-dimethyl-9S-(6-((S)-oxiran-2-yl)-6-oxohexyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone |
| Synonyms: | |
| 分子量: | 436.5 |
| 分子式: | C21H32N4O6 |
| SMILES: | [H][C@@]12C(N([H])[C@@H](C)C(N([H])[C@H](C)C(N([H])[C@](CCCCCC([C@@H]3CO3)=O)([H])C(N1CCC2)=O)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HC-Toxin 是一种环状四肽，是一种有效的HDAC抑制剂，IC50为 30 nM。HC-Toxin 可诱导肿瘤细胞凋亡 (apoptosis) 并具有抗癌作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Brosch, G., Ransom, R., Lechner, T., et al.Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonumPlant Cell7,1941-1950(1995)
Darkin-Rattray, S.J., Gurnett, A.M., Myers, R.W., et al.Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylaseProc. Natl. Acad. Sci. USA93(23),13143-13147(1996)
Kamitani, H., Taniura, S., Ikawa, H., et al.Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinomaCarcinogenesis22(1),187-191(2001)
Cao, H., and Stamatoyannopoulos, G.Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobinAm. J. Hematol.81,981-983(2006)
Walton, J.D.HC-toxinPhytochemistry67,1406-1413(2006)
