Phthalazinone pyrazole
Cat. No.：YN290826
| 产品名称: | Phthalazinone pyrazole |
| CAS No.: | 880487-62-7 |
| Chemical Name: | 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1(2H)-phthalazinone |
| Synonyms: | |
| 分子量: | 317.4 |
| 分子式: | C18H15N5O |
| SMILES: | O=C1C2=C(C=CC=C2)C(NC3=NNC(C)=C3)=NN1C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Phthalazinone pyrazole 是一种有效的、选择性的、具有口服活性的Aurora-A激酶抑制剂，其IC50值为 0.031 μM。Phthalazinone pyrazole 可以阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。Phthalazinone pyrazole 抑制人胚胎干细胞向肝细胞样细胞 (HLC) 分化过程中的上皮间质转化 (EMT)。 |
| IC50和靶点: | [{name:"Aurora-A:0.031 μM (IC50)"}] |
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| Solvent & Solubility: |
Moore, A.S., Blagg, J., Linardopoulos, S., et al.Aurora kinase inhibitors: Novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemiasLeukemia24(4),671-678(2010)
Yan, A., Wang, L., Xu, S., et al.Aurora-A kinase inhibitor scaffolds and binding moleculesDrug Discov. Today16(5-6),260-269(2011)
Prime, M., Courtney, S.M., Frederick, A.B., et al.Phthalazinone pyrazoles as potent, selective and orally bioavailable inhibitor of Aurora-A kinaseJ. Med. Chem.54(1),312-3191(2011)
