KU-0060648
Cat. No.：YN290827
| 产品名称: | KU-0060648 |
| CAS No.: | 881375-00-4 |
| Chemical Name: | 4-ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide |
| Synonyms: | KU0060648,KU 0060648 |
| 分子量: | 582.7 |
| 分子式: | C33H34N4O4S |
| SMILES: | O=C(CN1CCN(CC)CC1)NC2=CC=C(C3=CC=CC4=C3OC(N5CCOCC5)=CC4=O)C6=C2C(C=CC=C7)=C7S6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | KU-0060648 是PI3K和DNA-PK的双重抑制剂，抑制PI3Kα,PI3Kβ,PI3Kγ,PI3Kδ和DNA-PK的IC50值分别为 4 nM，0.5 nM，0.1 nM，0.594 nM 和 8.6 nM 。 |
| IC50和靶点: | [{name:"PI3Kα:4 nM (IC50)"},{name: "PI3Kβ:0.5 nM (IC50)"},{name: "PI3Kγ:0.594 μM (IC50)"},{name: "PI3Kδ:0.1 nM (IC50)"},{name: "DNA-PK:8.6 nM (IC50)"}] |
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Munck, J.M., Batey, M.A., Zhao, Y., et al.Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3KMol. Cancer Ther.11(8),1789-1798(2012)
Robert, F., Barbeau, M., Éthier, S., et al.Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editingGenome Med.7,93(2015)
Chen, M.-B., Zhou, Z.-T., Yang, L., et al.KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanismsOncotarget7(13),17047-17059(2016)
Lan, T., Zhao, Z., Qu, Y., et al.Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signalingOncotarget7(34),55555-55571(2016)
