JH-XVI-178
Cat. No.：YN290834
CAS No. ：916440-85-2
| 产品名称: | JH-XVI-178 |
| CAS No.: | 916440-85-2 |
| Chemical Name: | 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | 7-Bromoindirubin-3-Oxime |
| 分子量: | 356.2 |
| 分子式: | C16H10BrN3O2 |
| SMILES: | O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C(Br)C=CC=C4/3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7BIO (7-Bromoindirubin-3-Oxime) 是靛玉红的衍生物。7BIO (7-Bromoindirubin-3-Oxime) 对细胞周期蛋白依赖性激酶5 (CDK5) 和糖原合酶激酶-3β (GSK3β) 具有抑制作用。7BIO (7-Bromoindirubin-3-Oxime) 抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化，并减轻 Aβ 寡聚体诱导的小鼠认知障碍。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ribas, J., Bettayeb, K., Ferandin, Y., et al.7-Bromoindirubin-3'-oxime induces caspase-independent cell deathOncogene25(47),6304-6318(2006)
Ferandin, Y., Bettayeb, K., Kritsanida, M., et al.3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agentsJ. Med. Chem.49(15),4638-4649(2006)
Myrianthopoulos, V., Kritsanida, M., Gaboriaud-Kolar, N., et al.Novel inverse binding mode of indirubin derivatives yields improved selectivity for DYRK kinasesACS Med. Chem. Lett.4(1),22-26(2013)
Myrianthopoulos, V., Magiatis, P., Ferandin, Y., et al.An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubinsJ. Med. Chem.50(17),4027-4037(2007)
