HBX 41108
Cat. No.：YN290836
CAS No. ：924296-39-9
| 产品名称: | HBX 41108 |
| CAS No.: | 924296-39-9 |
| Chemical Name: | 7-chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile |
| Synonyms: | 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile;7-Chloro-9-oxo-9H-indeno[1,2-b]-pyrazine-2,3-dicarbonitrile;7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile DISCONTINUED;HBX 41108 |
| 分子量: | 266.6 |
| 分子式: | C13H3ClN4O |
| SMILES: | O=C1C2=NC(C#N)=C(C#N)N=C2C3=C1C=C(Cl)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HBX 41108 是泛素特异性蛋白酶 7 (USP7)的非竞争性抑制剂，IC50为 424 nM。HBX 41108 抑制USP7介导的 p53 去泛素化以稳定 p53 并抑制癌细胞生长。HBX 41108 诱导 p53 依赖的凋亡。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Colland, F., Formstecher, E., Jacq, X., et al.Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cellsMol. Cancer Ther.8(8),2286-2295(2009)
