AS1892802
Cat. No.：YN290837
CAS No. ：928320-12-1
| 产品名称: | AS1892802 |
| CAS No.: | 928320-12-1 |
| Chemical Name: | N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea |
| Synonyms: | |
| 分子量: | 333.4 |
| 分子式: | C20H19N3O2 |
| SMILES: | O=C(N[C@H](CO)C1=CC=CC=C1)NC(C=C2)=CC=C2C3=CC=NC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AS1892802 是一种有效的、具有口服活性的、高度选择性的ROCK抑制剂。AS1892802 的镇痛作用起效与曲马多和双氯芬酸一样快。AS1892802 不会引起胃刺激或异常行为。AS1892802 是用于研究严重骨关节炎疼痛的一种有吸引力的镇痛剂。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Yoshimi, E., Kumakura, F., Hatori, C., et al.Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritisJ. Pharmacol. Exp. Ther.334(3),955-963(2010)
Yoshimi, E., Yamamoto, H., Furuichi, Y., et al.Sustained analgesic effect of the Rho kinase inhibitor AS1892802 in rat models of chronic painJ. Pharmacobiodyn114(1),119-122(2010)
Takeshita, N., Yoshimi, E., Hatoria, C., et al.Alleviating effects of AS1892802, a Rho kinase inhibitor, on osteoarthritic disorders in rodentsJ. Pharmacol. Sci.115(4),481-489(2011)
