Remodelin
Cat. No.：YN310531
| 产品名称: | Remodelin |
| CAS No.: | 949912-58-7 |
| Chemical Name: | 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile |
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| 分子量: | 282.4 |
| 分子式: | C15H14N4S |
| SMILES: | N#CC1=CC=C(C2=CSC(N/N=C3CCCC\3)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Remodelin是一种具有口服活性的乙酰基转移酶 NAT10的选择性抑制剂。Remodelin 抑制前列腺癌细胞中 NAT10 活性，减缓 DNA 复制，抑制细胞生长。Remodelin 在异种移植模型中抑制前列腺癌和肝细胞性肝癌的生长，并能延长早年衰老综合症鼠模型的健康寿命。 |
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Larrieu, D., Britton, S., Demir, M., et al.Chemical inhibition of NAT10 corrects defects of laminopathic cellsScience344(6183),527-532(2014)
Chimenti, F., Bizzarri, B., Maccioni, E., et al.Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida sppBioorg. Med. Chem. Lett.17(16),4635-4640(2007)
