Garcinone C
Cat. No.：YN290842
CAS No. ：956025-83-5
| 产品名称: | Garcinone C |
| CAS No.: | 956025-83-5 |
| Chemical Name: | 1-(1,1-dimethylethyl)-3-[(3-methylphenyl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Synonyms: | |
| 分子量: | 295.4 |
| 分子式: | C17H21N5 |
| SMILES: | NC1=C(C(CC2=CC=CC(C)=C2)=NN3C(C)(C)C)C3=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 3MB-PP1 是一种体积庞大的嘌呤类似物，是一种 Polo 样激酶 1 (Plk1) 抑制剂。3MB-PP1 通过靶向Plk1阻断表达类似物敏感的Plk1等位基因的细胞有丝分裂进程和细胞分裂。3MB-PP1 特异性抑制类似物敏感的Ssn3(Cdk8) 的活性。3MB-PP1 抑制 Leu93 突变 Zipper-interacting protein kinase(Leu93-ZIPK；IC50=2 μM)。3MB-PP1 可用于白色念珠菌 (Candida albicans) 的菌丝形成和细胞分裂研究 |
| IC50和靶点: | [{name:"Leu93-ZIPK:2 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Cipak, L., Zhang, C., Kovacikova, I., et al.Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombeCell Cycle10(20),3527-3532(2011)
Tay, Y.D., Patel, A., Kaemena, D.F., et al.Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeastJ. Cell Sci.126(Pt 21),5052-5061(2013)
Burkard, M.E., Santamaria, A., and Jallepalli, P.V.Enabling and disabling polo-like kinase 1 inhibition through chemical geneticsACS Chem. Biol.7(6),978-981(2012)
