NCT-58
Cat. No.：YN290845
| 产品名称: | NCT-58 |
| CAS No.: | 959763-06-5 |
| Chemical Name: | 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-butanamide |
| Synonyms: | |
| 分子量: | 415.9 |
| 分子式: | C19H18ClN5O2S |
| SMILES: | NC1=NC(SCCCC(N)=O)=NC(C2=C(Cl)C=C3C4=C2C=CC=C4COC3)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CH5138303 是一种口服有效的Hsp90抑制剂。CH5138303 与Hsp90αN 端具有较高的结合亲和力，Kd为 0.52 nM。CH5138303 对人癌细胞 (HCT116 和 NCI-N87) 具有较强的抗增殖活性，其IC50值分别为 0.098 和 0.066 μM。CH5138303 小鼠口服生物利用度高 (F=44.0%)。CH5138303 在人 NCI-N87 胃癌异种移植模型中显示出强大的抗肿瘤作用。 |
| IC50和靶点: | [{name:"HSP90α:0.52 nM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Suda, A., Kawasaki, K., Komiyama, S., et al.Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitorsBioorg. Med. Chem.22(2),892-905(2014)
