CC-90005
Cat. No.：YN310539
| 产品名称: | CC-90005 |
| CAS No.: | 1799574-70-1 |
| Chemical Name: | |
| Synonyms: | GEZ43HM6NW;GTPL11659;compound 57 [PMID: 34355886];2-(((4-(2,2-difluoropropoxy)pyrimidin-5-yl)methyl)amino)-4-(((1R,4S)-4-hydroxy-3,3-dimethylcyclohexyl)amino)pyrimidine-5-carbonitrile;2-(((4-(2,2-difluoropropoxyl)pyrimidin-5-yl)methyl)amino)-4-(((1R,4S)-4 |
| 分子量: | 447.4816 |
| 分子式: | C21H27F2N7O2 |
| SMILES: | FC(C([H])([H])[H])(C([H])([H])OC1C(=C([H])N=C([H])N=1)C([H])([H])N([H])C1=NC([H])=C(C#N)C(=N1)N([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])O[H])F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CC-90005 是一种有效，选择性和具有口服活性的蛋白激酶 C-θ (PKC-θ) 抑制剂，IC50值为 8 nM。CC-90005 显示了对 PKC-θ 的选择性超过 PKC-δ (IC50=4440 nM)。CC-90005 可以通过抑制IL-2表达抑制 T 细胞活化。 |
| IC50和靶点: | [{name:"PKCθ:8 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
