Mirin
Cat. No.:YN290889
CAS No. :299953-00-7
产品名称: | Mirin |
CAS No.: | 299953-00-7 |
Chemical Name: | 2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone |
Synonyms: | |
分子量: | 220.3 |
分子式: | C10H8N2O2S |
SMILES: | N=C(S/C1=C\C2=CC=C(O)C=C2)NC1=O |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | Mirin 一种有效的Mre11-Rad50-Nbs1 (MRN)复合物抑制剂。Mirin 在不影响ATM蛋白激酶活性的情况下阻止ATM(ataxia-telangiectasia mutated) 的 MRN 依赖性激活 (IC50=12 μM),并抑制 Mre11 相关的核酸外切酶活性。Mirin 可消除哺乳动物细胞中的 G2/M 检查点和同源性依赖性修复。Mirin 在哺乳动物细胞中阻止ATM因 DNA 双链断裂 (DSBs) 而激活并阻断同源性定向修复 (HDR)。 |
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Dupré, A., Boyer-Chatenet, L., Sattler, R.M., et al.A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complexNat. Chem. Biol.4(2),119-125(2008)
Petroni, M., Sardina, F., Infante, P., et al.MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumorsCell Death Dis.9(9),895(2018)