ML291
Cat. No.:YN290900
CAS No. :1523437-16-2
产品名称: | ML291 |
CAS No.: | 1523437-16-2 |
Chemical Name: | N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-2-furancarboxamide |
Synonyms: | |
分子量: | 413.8 |
分子式: | C16H16ClN3O6S |
SMILES: | ClC1CCN(S(C2=CC=C(NC(C3=CC=C([N+]([O-])=O)O3)=O)C=C2)(=O)=O)CC1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | ML291 是一种 UPR (未折叠蛋白反应)诱导的磺胺苯甲酰胺。ML291 在多种实体肿瘤模型中破坏 UPR 的适应能力,诱导细胞凋亡。ML291 可激活 UPR 的凋亡分支PERK/eIF2a/CHOP,减少白血病细胞负担。 |
IC50和靶点: | |
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In Vivo: | |
Clinical Trial: | |
Solvent & Solubility: |
Flaherty, D.P., Golden, J.E., Liu, C., et al.Selective small molecule activator of the apoptotic arm of the UPRProbe Reports from the NIH Molecular Libraries Program,(2012)