JAK2-IN-7
Cat. No.：YN310561
CAS No. ：2593402-36-7
| 产品名称: | JAK2-IN-7 |
| CAS No.: | 2593402-36-7 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 459.598 |
| 分子式: | C26H33N7O |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JAK2-IN-7 是一种选择性JAK2抑制剂，对JAK2，SET-2 和 Ba/F3V617F细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是JAK1,JAK3，FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期，并诱导肿瘤细胞凋亡 (apoptosis)。抗肿瘤活性。 |
| IC50和靶点: | [{name:"JAK1:42 nM (IC50)"},{name: "JAK2:3 nM (IC50)"},{name: "JAK3:94 nM (IC50)"},{name: "Tyk2:75 nM (IC50)"},{name: "FLT3:62 nM (IC50)"}] |
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