CDK8-IN-12
Cat. No.：YN310593
| 产品名称: | CDK8-IN-12 |
| CAS No.: | 2613307-67-6 |
| Chemical Name: | |
| Synonyms: | |
| 分子量: | 381.86 |
| 分子式: | C21H20ClN3O2 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CDK8-IN-12 是一种具有口服活性的有效CDK8抑制剂，Ki为 14 nM。CDK8-IN-12 对 GSK-3α、GSK-3β、PCK-θ 具有脱靶激酶抑制作用，Ki分别为 13 nM、4 nM、109 nM。CDK8-IN-12 选择性地对 MV4-11 细胞显示出有效的抗增殖作用。CDK8-IN-12 是一种抗癌剂。 |
| IC50和靶点: | [{name:"CDK8:14 nM (Ki)"},{name: "GSK-3α:13 nM (Ki)"},{name: "GSK-3β:4 nM (Ki)"},{name: "PKCθ:109 nM (Ki)"}] |
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