EB-47
Cat. No.：YN291001
| 产品名称: | EB-47 |
| CAS No.: | 366454-36-6 |
| Chemical Name: | 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide |
| Synonyms: | |
| 分子量: | 537.53 |
| 分子式: | C24H27N9O6 |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EB-47 是一种有效的PARP-1/ARTD-1选择性抑制剂，IC50值为 45 nM，对 ARTD5 的IC50值为 410 nM，表现出温和的药效。EB-47 模拟底物 NAD+，从烟酰胺延伸至腺苷亚区结合。 |
| IC50和靶点: | [{name:"ARTD1/PARP1:45 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jagtap, et al.: Bioorg. Med. Chem. Lett., 14, 81 (2004), Gaymes, et al.: Haematologica, 94, 638 (2009), Ferraris, et al.: J. Med. Chem. 53, 4561 (2010),
