CCPA
Cat. No.：YN291002
| 产品名称: | CCPA |
| CAS No.: | 37739-05-2 |
| Chemical Name: | 2-chloro-N-cyclopentyl-adenosine |
| Synonyms: | 2-Chloro-N6-cyclopentyladenosine |
| 分子量: | 369.8033 |
| 分子式: | C15H20ClN5O4 |
| SMILES: | OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C(NC4CCCC4)N=C(Cl)N=C32)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CCPA (2-Chloro-N6-cyclopentyladenosine) 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性，靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成，诱导细胞凋亡 (apoptosis) 等。 |
| IC50和靶点: | |
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Lohse, M.J., Klotz, K.N., Schwabe, U., et al.2-Chloro-N6-cyclopentyladenosine: A highly selective agonist at A1 adenosine receptorsNaunyn Schmiedebergs Arch Pharmacol.337(6),687-689(1988)
Łuszczki, J.J., Kozicka, M., Swiader, M.J., et al.2-Chloro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure modelPharmacol. Rep.57(6),787-794(2005)
Tsuchida, A., Liu, G.S., Wilborn, W.H., et al.Pretreatment with the adenosine A1 selective agonist, 2-chloro-N6-cyclopentyladenosine (CCPA), causes a sustained limitation of infarct size in rabbitsCardiovasc Res.27(4),652-656(1993)
