Butyrolactone I
Cat. No.：YN291029
| 产品名称: | Butyrolactone I |
| CAS No.: | 87414-49-1 |
| Chemical Name: | (2R)-2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-2-furancarboxylic acid, methyl ester |
| Synonyms: | Olomoucin |
| 分子量: | 424.5 |
| 分子式: | C24H24O7 |
| SMILES: | O=C1O[C@@](CC2=CC(C/C=C(C)/C)=C(O)C=C2)(C(OC)=O)C(C3=CC=C(O)C=C3)=C1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Butyrolactone I 是CDK1的 ATP 竞争性抑制剂，是A.terreus的次级代谢产物。Butyrolactone I 在非小细胞肺癌、小细胞肺癌和前列腺癌细胞系中具有抗肿瘤作用。 |
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Nishio, K., Arioka, H., Kurokawa, H., et al.Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines.Anticancer Res.16(6B),3387-3395(1996)
Suzuki, M., Hosaka, Y., Matsushima, H., et al.Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines.Cancer Lett.138(1-2),121-130(1999)
Hosoi, T., Uchiyama, M., Okumura, E., et al.Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract.J. Biochem.117(4),741-749(1995)
Kitagawa, M., Higashi, H., Suzuki-Takahashi, I., et al.Phosphorylation of E2F-1 by cyclin A-cdk2.Oncogene10(2),229-236(1995)
Palonen, E.K., Raina, S., Brandt, A., et al.Transcriptomic complexity of Aspergillus terreus velvet gene family under the influence of butyrolactone I.Microorganisms14;5(1),(2017)
