STAMBP-IN-1
Cat. No.：YN291030
CAS No. ：896683-78-6
| 产品名称: | STAMBP-IN-1 |
| CAS No.: | 896683-78-6 |
| Chemical Name: | 2-[[3,4-Dihydro-6-(4-morpholinyl)-4-oxo-3-(2-phenylethyl)-2-quinazolinyl]thio]-N-(2-furanylmethyl)-acetamide |
| Synonyms: | |
| 分子量: | 504.61 |
| 分子式: | C27H28N4O4S |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | STAMBP-IN-1 是 STAMBP去泛素酶的小分子抑制剂，能中断STAMBP-Ub-NALP7的相互作用。在 Toll 样受体 (TLR) 激动后，STAMBP-IN-1 能够降低炎性小体底物NALP7的蛋白水平，抑制IL-1b释放。STAMBP- in -1 抑制了 STAMBP 裂解重组蛋白 di-Ub 的活性，IC50为 0.33 mM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bednash JS, et al. Nat Commun.8, (2018)
