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SMER28

Cat. No.:YN280002

  • CAS No. :307538-42-7

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    • 生物活性
    • 参考文献
    • 产品名称: SMER28
      CAS No.: 307538-42-7
      Chemical Name: 6-bromo-N-2-propen-1-yl-4-quinazolinamine
      Synonyms:
      分子量:264.12
      分子式:C₁₁H₁₀BrN₃
      SMILES:C=CCNC1=C2C=C(Br)C=CC2=NC=N1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: SMER28 是一个调节自噬的、独立于 mTOR 信号通路机制的小分子阳性调节剂,能够阻止β淀粉样蛋白肽的累积。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Sarkar, S., Perlstein, E.O., Imarisio, S., et al.Small molecules enhance autophagy and reduce toxicity in Huntington's disease modelsNat. Chem. Biol.3(6),331-338(2007)

      Renna, M., Jiminez-Sanchez, M., Sarkar, S., et al.Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseasesJ. Biol. Chem.285(15),11061-11067(2010)

      Shen, D., Coleman, J., Chan, E., et al.Novel cell- and tissue-based assays for detecting misfolded and aggregated protein accumulation within aggresomes and inclusion bodiesCell Biochem. Biophys.60(3),173-185(2011)

      Tian, Y., Bustos, V., Flajolet, M., et al.A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathwayFASEB J.25(6),1934-1942(2011)

      Zhang, M., Lin, Y.H., Sun, Y.J., et al.Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activationCell Stem Cell18(5),653-667(2016)

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