AS1842856
Cat. No.：YN280005
CAS No. ：836620-48-5
| 产品名称: | AS1842856 |
| CAS No.: | 836620-48-5 |
| Chemical Name: | 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid |
| Synonyms: | 3-Quinolinecarboxylic acid,5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-;AS1842856;AS-1842856 |
| 分子量: | 347.38 |
| 分子式: | C₁₈H₂₂FN₃O₃ |
| SMILES: | O=C(C1=CN(CC)C2=C(C(N)=C(F)C(NC3CCCCC3)=C2)C1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AS1842856 是一种特异性的Foxo1抑制剂，IC50为 30 nM，AS1842856 有效抑制自噬 (autophagy)。AS1842856 仅通过与 FoxO1 结合而降低 FoxO1 的活性，而不影响其转录和蛋白质表达。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Nagashima, T., Shigematsu, N., Maruki, R., et al.Discovery of novel forkhead box O1 inhibitors for treating Type 2 Diabetes: Improvement of fasting glycemia in diabetic db/db miceMol. Pharmacol.78(5),961-970(2010)
Liu, L., Zheng, L.D., Zou, P., et al.FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytesCell Cycle15(15),2033-2041(2016)
Zou, P., Liu, L., Zheng, L., et al.Targeting FoxO1 with AS1842856 suppresses adipogenesisCell Cycle13(23),3759-3767(2014)
