Tozasertib
Cat. No.：YN280011
CAS No. ：639089-54-6
| 产品名称: | Tozasertib |
| CAS No.: | 639089-54-6 |
| Chemical Name: | N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-cyclopropanecarboxamide |
| Synonyms: | VX 680; MK-0457 |
| 分子量: | 464.59 |
| 分子式: | C₂₃H₂₈N₈OS |
| SMILES: | CC1=CC(NC2=NC(SC3=CC=C(C=C3)NC(C4CC4)=O)=NC(N5CCN(CC5)C)=C2)=NN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tozasertib (VX 680; MK-0457) 是Aurora A/B/C 激酶抑制剂，Ki值分别为 0.6，18，4.6 nM。 |
| IC50和靶点: | [{name:"Aurora A:0.6 nM (Ki)"},{name: "Aurora B:18 nM (Ki)"},{name: "Aurora C:4.6 nM (Ki)"}] |
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| Solvent & Solubility: |
Li, Y., Zhang, Z.F., Chen, J., et al.VX680/MK-0457, a potent and selective Aurora kinase inhibitor, targets both tumor and endothelial cells in clear cell renal cell carcinomaAm. J. Transl. Res.2(3),296-308(2010)
Pollard, J.R., and Mortimore, M.Discovery and development of Aurora kinase inhibitors as anticancer agentsJ. Med. Chem.52(9),2629-2651(2009)
