Danusertib
Cat. No.：YN280016
CAS No. ：827318-97-8
| 产品名称: | Danusertib |
| CAS No.: | 827318-97-8 |
| Chemical Name: | 4-(4-methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]-benzamide |
| Synonyms: | PHA-739358 |
| 分子量: | 474.55 |
| 分子式: | C₂₆H₃₀N₆O₃ |
| SMILES: | O=C(N1CC2=C(NN=C2NC(C3=CC=C(N4CCN(CC4)C)C=C3)=O)C1)[C@@H](C5=CC=CC=C5)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Danusertib 是一种极光激酶 (aurora kinase) 抑制剂，能够抑制 Aurora A，Aurora B 和 Aurora C 的活性，IC50值分别为 13，79 和 61 nM。 |
| IC50和靶点: | [{name:"Aurora A:13 nM (IC50)"},{name: "Aurora B:79 nM (IC50)"},{name: "Aurora C:61 nM (IC50)"}] |
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Carpinelli, P., Ceruti, R., Giorgini, M.L., et al.PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancerMol. Cancer Ther.6(12 Pt 1),3158-3153(2007)
Gontarewicz, A., Balabanov, S., Keller, G., et al.Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315IBlood111(8),4355-4364(2008)
Moore, A.S., Blagg, J., Linardopoulos, S., et al.Aurora kinase inhibitors: Novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemiasLeukemia24(4),671-678(2010)
