Autophinib
Cat. No.：YN280017
CAS No. ：1644443-47-9
| 产品名称: | Autophinib |
| CAS No.: | 1644443-47-9 |
| Chemical Name: | 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-4-pyrimidinamine |
| Synonyms: | Autophinib;6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine;6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine;BCP25844;BDBM50543600;s8596;ZB1499 |
| 分子量: | 346.73 |
| 分子式: | C₁₄H₁₁ClN₆O₃ |
| SMILES: | CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Autophinib 是一种有效的，选择性细胞自噬抑制剂，对于饥饿和 Rapamycin 诱导的自噬，IC50值分别为 90 nM 和 40 nM。Autophinib 还是一种 ATP 竞争性的VPS34抑制剂，其IC50值为 19 nM。Autophinib 通过靶向VPS34来抑制饥饿或 Rapamycin 诱导的细胞自噬。 |
| IC50和靶点: | [{name:"Vps34:19 nM (IC50)"}] |
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| Solvent & Solubility: |
Robke, L., Laraia, L., Carnero Corrales, M.A., et al.Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34Angew. Chem. Int. Ed. Engl.56(28),8153-8157(2017)
