Pemetrexed
Cat. No.：YN280021
| 产品名称: | Pemetrexed |
| CAS No.: | 137281-23-3 |
| Chemical Name: | N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid; NSC 698037; Pemetrexed; Pemetrexed EP Impurity E, |
| Synonyms: | 培美曲塞; LY231514 |
| 分子量: | 427.41 |
| 分子式: | C₂₀H₂₁N₅O₆ |
| SMILES: | O=C1NC(N)=NC2=C1C(CCC3=CC=C(C(N[C@H](C(O)=O)CCC(O)=O)=O)C=C3)=CN2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pemetrexed (LY231514) 是一种叶酸拮抗剂 (antifolate)。Pemetrexed (LY231514) 抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)，Ki分别为 1.3 nM，7.2 nM 和 65 nM。 |
| IC50和靶点: | |
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| In Vivo: | |
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| Solvent & Solubility: |
Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012)
