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Vinorelbine ditartrate

Cat. No.:YN280034

  • CAS No. :125317-39-7

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Vinorelbine ditartrate
      CAS No.: 125317-39-7
      Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-aspidospermidine-3-carboxylic acid, methyl ester, 2R,3R-dihydroxybuta
      Synonyms:酒石酸长春瑞滨; KW-2307; Nor-5'-anhydrovinblastine ditartrate
      分子量:1079.11
      分子式:C₅₃H₆₆N₄O₂₀
      SMILES:CC[C@@]1(C=CCN2CC3)[C@@]2([H])[C@@]3(C(C=C([C@@](C4=C5C(C=CC=C6)=C6N4)(CC(C=C(CC)C7)([H])CN7C5)C(OC)=O)C(OC)=C8)=C8N9C)[C@]9([H])[C@](C(OC)=O)(O)[C@@H]1OC(C)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Vinorelbine ditartrate 是一种抗有丝分裂剂,能够抑制 Hela 细胞的增殖,IC50值为 1.25 nM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Jordan, M.A., and Wilson, L.Microtubules as a target for anticancer drugsNat. Rev. Cancer4(4),253-265(2004)

      Kingston, D.G.I.Tubulin-interactive natural products as anticancer agentsJ. Nat. Prod.72(3),507-515(2009)

      Ngan, V.K., Bellman, K., Hill, B.T., et al.Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunineMol. Pharmacol.60(1),225-232(2001)

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