ALLO-1
Cat. No.：YN280035
CAS No. ：37468-32-9
| 产品名称: | ALLO-1 |
| CAS No.: | 37468-32-9 |
| Chemical Name: | 3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-imidazolidinedione |
| Synonyms: | ALLO-1;1-Benzyl-3-(4-chlorophenyl)-5-methyl-2,4-imidazolidinedione;1-Benzyl-3-(4-carbamoylphenoxy)-pyrrolidin;1-benzyl-3-(4-chloro-phenyl)-5-methyl-imidazolidine-2,4-dione;4-(1-BENZYLPYRROLIDIN-3-YLOXY)BENZAMIDE;AG-E-91623;Benzamide,4-[[1-(phenylmethyl)-3 |
| 分子量: | 314.77 |
| 分子式: | C₁₇H₁₅ClN₂O₂ |
| SMILES: | O=C1N(C(N(C1C)CC2=CC=CC=C2)=O)C3=CC=C(C=C3)Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ALLO-1 是一种自噬受体，在父系细胞器周围形成自噬体是必不可少的，ALLO-1 通过与秀丽隐杆线虫的 LC3 相互作用区 (LIR) 直接与蠕虫 LC3 同系物 LGG-1 结合。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ruiz-Gómez, A., Molnar, C., Holguín, H., et al.The cell biology of Smo signalling and its relationships with GPCRsBiochim. Biophys. Acta1768(4),901-912(2007)
Rubin, L.L., and de Sauvage, F.J.Targeting the Hedgehog pathway in cancerNat. Rev. Drug Discov.5(12),1026-1033(2006)
Tao, H., Jin, Q., koo, D.I., et al.Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothenedChem. Biol.18,432-437(2011)
Sharpe, H.J., Wang, W., Hannoush, R.N., et al.Regulation of the oncoprotein Smoothened by small moleculesNat. Chem. Biol.11,246-255(2015)
