PFK-015
Cat. No.：YN280036
CAS No. ：4382-63-2
| 产品名称: | PFK-015 |
| CAS No.: | 4382-63-2 |
| Chemical Name: | 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one |
| Synonyms: | PFK-015 |
| 分子量: | 260.29 |
| 分子式: | C₁₇H₁₂N₂O |
| SMILES: | O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC=CC=C3C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PFK-015是PFKFB3抑制剂，对重组PFKFB3的IC50为110 nM，能抑制肿瘤细胞内PFKFB3活性，IC50为20 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Atsumi, T., Chesney, J., Metz, C., et al.High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancersCancer Res.62(20),5881-5887(2002)
Seo, M., Kim, J.D., Neau, D., et al.Structure-based development of small molecule PFKFB3 inhibitors: A framework for potential cancer therapeutic agents targeting the Warburg effectPLoS One6(9),e24179(2011)
Clem, B.F., O'Neal, J., Tapolsky, G., et al.Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancerMol. Cancer Ther.12(8),1461-1470(2013)
