BL-918
Cat. No.：YN280040
CAS No. ：2101517-69-3
| 产品名称: | BL-918 |
| CAS No.: | 2101517-69-3 |
| Chemical Name: | αR-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-benzeneacetamide |
| Synonyms: | BL918；BL 918；BL-918 |
| 分子量: | 533.44 |
| 分子式: | C₂₃H₁₅F₈N₃OS |
| SMILES: | O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=S)C3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BL-918 是一种具有口服活性 UNC-51 样激酶 1 (ULK1) 激活剂，EC50为 24.14 nM。BL-918 通过靶向 ULK 复合物发挥其细胞保护性自噬作用。BL-918 有用于帕金森氏病 (PD) 的潜力。 |
| IC50和靶点: | [{name:"ULK1:24.14 nM (EC50)"},{name: "ULK1:0.719 μM (Kd)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Ouyang, L., Zhang, L., Zhang, S., et al.Small-molecule activator of UNC-51-like kinase 1 (ULK1) that induces cytoprotective autophagy for Parkinson's disease treatmentJ. Med. Chem.61(7),2776-2792(2018)
