Lys05
Cat. No.：YN280050
CAS No. ：1391426-24-6
| 产品名称: | Lys05 |
| CAS No.: | 1391426-24-6 |
| Chemical Name: | N2-(7-chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine, trihydrochloride |
| Synonyms: | Lys01 trihydrochloride |
| 分子量: | 549.75 |
| 分子式: | C₂₃H₂₆Cl₅N₅ |
| SMILES: | CN(CCNC1=CC=NC2=C1C=CC(Cl)=C2)CCNC3=CC=NC4=CC(Cl)=CC=C43.[H]Cl.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lys05 (Lys01 trihydrochloride) 是新颖的溶酶体自噬 (lysosomal autophagy) 抑制剂。在MTT试验中，对1205Lu, c8161, LN229 和HT-29细胞系的IC50值分别为3.6, 3.8, 6 和7.9 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
McAfee, Q., Zhang, Q., Samanta, A., et al.Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiencyProc. Natl. Acad. Sci. USA109(21),8253-8258(2012)
