GSK2578215A
Cat. No.：YN280054
CAS No. ：1285515-21-0
| 产品名称: | GSK2578215A |
| CAS No.: | 1285515-21-0 |
| Chemical Name: | 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-benzamide |
| Synonyms: | 5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 |
| 分子量: | 399.42 |
| 分子式: | C₂₄H₁₈FN₃O₂ |
| SMILES: | FC1=NC=CC(C2=CC(C(NC3=CC=CN=C3)=O)=C(OCC4=CC=CC=C4)C=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK2578215A 是 一种有效的选择性LRRK2抑制剂，作用于野生型 LRRK2 和 G2019S 突变型，IC50值都约为 10 nM。 |
| IC50和靶点: | |
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Reith, A.D., Bamborough, P., Jandu, K., et al.GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitorBioorg. Med. Chem. Lett.22(17),5625-5629(2012)
Saez-Atienzar, S., Bonet-Ponce, L., Blesa, J.R., et al.The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: Involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signalingCell Death Dis.14(5),e1368(2014)
Yan, J., Almilaji, A., Schmid, E., et al.Leucine-rich repeat kinase 2-sensitive Na+/Ca2+ exchanger activity in dendritic cellsFASEB J.29(5),1701-1710(2015)
