GSK343
Cat. No.：YN280059
CAS No. ：1346704-33-3
| 产品名称: | GSK343 |
| CAS No.: | 1346704-33-3 |
| Chemical Name: | N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide |
| Synonyms: | 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide;GSK343;1-(1-Methylethyl)-N-;1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6- |
| 分子量: | 541.69 |
| 分子式: | C₃₁H₃₉N₇O₂ |
| SMILES: | O=C(C1=CC(C2=CC(N3CCN(C)CC3)=NC=C2)=CC4=C1C=NN4C(C)C)NCC5=C(CCC)C=C(C)NC5=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK343 是一种高效,选择性的EZH2抑制剂，IC50为 4 nM。 |
| IC50和靶点: | |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Simon, J.A., and Lange, C.A.Roles of the EZH2 histone methyltransferase in cancer epigeneticsMutat. Res.647(1-2),21-29(2008)
Verma, S.K., Tian, X., LaFrance, L.V., et al.Identification of potent, selective, cell-active inhibitors of the histone lysine methyltransferase EZH2ACS Med. Chem. Lett.3(12),1091-1096(2012)
