Amsacrine hydrochloride
Cat. No.：YN280061
CAS No. ：54301-15-4
| 产品名称: | Amsacrine hydrochloride |
| CAS No.: | 54301-15-4 |
| Chemical Name: | N-[4-(9-acridinylamino)-3-methoxyphenyl]-methanesulfonamide, monohydrochloride |
| Synonyms: | m-AMSA hydrochloride; acridinyl anisidide hydrochloride |
| 分子量: | 429.92 |
| 分子式: | C₂₁H₂₀ClN₃O₃S |
| SMILES: | CS(=O)(NC1=CC=C(NC2=C(C=CC=C3)C3=NC4=CC=CC=C42)C(OC)=C1)=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) 是肿瘤细胞 DNA 嵌入剂，还能抑制拓扑异构酶 II。 |
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Nelson, E.M., Tewey, K.M., and Liu, L.F.Mechanism of antitumor drug action: Poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidideProc. Natl. Acad. Sci. USA81(5),1361-1365(1984)
Drewinko, B., Yang, L.Y., and Barlogie, B.Lethal activity and kinetic response of cultured human cells to 4'-(9-acridinylamino)methanesulfon-m-anisidineCancer Res.42(1),107-111(1982)
Rozencweig, M., Von Hoff, D.D., Cysyk, R.L., et al.m-AMSA and PALA: Two new agents in cancer chemotherapyCancer Chemother. Pharmacol.3(3),135-141(1979)
