TFEB activator 1
Cat. No.：YN280062
CAS No. ：39777-61-2
| 产品名称: | TFEB activator 1 |
| CAS No.: | 39777-61-2 |
| Chemical Name: | (1E,4E)-1,5-bis(2-methoxyphenyl)-1,4-pentadien-3-one |
| Synonyms: | RPN77612,Curcumin analog compound C1,(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,,(1E,4E)-1,5(2 -甲氧基苯基)-1,4-戊二烯-3-酮,Curcumin analog C1 |
| 分子量: | 294.34 |
| 分子式: | C₁₉H₁₈O₃ |
| SMILES: | O=C(/C=C/C1=CC=CC=C1OC)/C=C/C2=CC=CC=C2OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TFEB activator 1 是一种口服有效的，不依赖 mTOR 的TFEB激活剂。TFEB activator 1 显着促进 Flag-TFEB 的核易位，EC50为 2167 nM。TFEB activator 1 在不抑制 mTOR 通路的情况下增强自噬 (autophagy)。TFEB activator 1 有潜力用于神经退行性疾病的研究。 |
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Yamakoshi, H., Ohori, H., Kudo, C., et al.Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereofBioorg. Med. Chem.18(3),1083-1092(2010)
Song, J.-X., Sun, Y.-R., Peluso, I., et al.A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibitionAutophagy12(8),1372-1389(2016)
