PR-619
Cat. No.：YN280070
| 产品名称: | PR-619 |
| CAS No.: | 2645-32-1 |
| Chemical Name: | thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester |
| Synonyms: | PR 619,2,6-Diamino-3,5-dithiocyanopyridine |
| 分子量: | 223.28 |
| 分子式: | C₇H₅N₅S₂ |
| SMILES: | NC1=C(SC#N)C=C(SC#N)C(N)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PR-619 是一种DUB抑制剂，作用于USP4，USP8，USP7，USP2和USP5，EC50分别为 3.93，4.9，6.86，7.2 和 8.61 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Altun, M., Kramer, H.B., Willems, L.I., et al.Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymesChem. Biol.18(11),1401-1412(2011)
Udeshi, N.D., Mani, D.R., Eisenhaure, T., et al.Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibitionMol. Cell. Proteomics11(15),148-159(2012)
Balut, C.M., Loch, C.M., and Devor, D.C.Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1FASEB J.25(11),3938-3948(2011)
Seiberlich, V., Goldbaum, O., Zhukareva, V., et al.The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: Implications for neurodegenerative diseasesBiochim. Biophys. Acta1823(11),2057-2068(2012)
Bertuccio, C.A., Lee, S.L., Wu, G., et al.Anterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independentPLoS One9(3),1-16(2014)
