Irinotecan hydrochloride trihydrate
Cat. No.：YN280093
CAS No. ：136572-09-3
| 产品名称: | Irinotecan hydrochloride trihydrate |
| CAS No.: | 136572-09-3 |
| Chemical Name: | [1,4'-bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, monohydrochloride, trihydrate |
| Synonyms: | 盐酸伊立替康三水合物; (+) |
| 分子量: | 677.18 |
| 分子式: | C₃₃H₄₅ClN₄O₉ |
| SMILES: | [H]Cl.O=C(N1CCC(N2CCCCC2)CC1)OC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3.O.O.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) 是一种拓扑异构酶 I (topoisomerase I) 抑制剂，可用于结肠癌和直肠癌的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Rothenberg, M.L.Topoisomerase I inhibitors: Review and updateAnn. Oncol.8(9),837-855(1997)
Dancey, J., and Eisenhauer, E.A.Current perspectives on camptothecins in cancer treatmentBr. J. Cancer74(3),327-338(1996)
Mathijssen, R.H.J., van Alphen, R.J., Verweij, J., et al.Clinical pharmacokinetics and metabolism of irinotecan (CPT-11)Clin. Cancer Res.7(8),2182-2194(2001)
Ma, M.K., and McLeod, H.L.Lessons learned from the irinotecan metabolic pathwayCurr. Med. Chem.10(1),41-49(2003)
