Genipin
Cat. No.：YN280099
| 产品名称: | Genipin |
| CAS No.: | 6902-77-8 |
| Chemical Name: | 1R,4aS,5,7aS-tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic acid, methyl ester |
| Synonyms: | 京尼平; (+) |
| 分子量: | 226.23 |
| 分子式: | C₁₁H₁₄O₅ |
| SMILES: | O=C(C1=CO[C@@H](O)[C@@]2([H])[C@]1([H])CC=C2CO)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Genipin ((+)-Genipin) 是衍生自Gardenia jasminoides Ellis果实的天然交联剂。Genipin 抑制细胞中的 UCP2 (解偶联蛋白 2)。Genipin 具有多种生物活性，包括蛋白质调节，抗肿瘤，抗炎症，免疫抑制，抗血栓形成和对海马神经元的保护。Genipin 也可用于 2 型糖尿病研究。 |
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Chan, C.B., De Leo, D., Joseph, J.W., et al.Increased uncoupling protein-2 levels in ß-cells are associated with impaired glucose-stimulated insulin secretion mechanism of actionDiabetes50(6),1302-1310(2001)
Zhang, C.Y., Baffy, G., Perret, P., et al.Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, ß cell dysfunction, and type 2 diabetesCell105(6),745-755(2001)
Sesti, G., Cardellini, M., Marini, M.A., et al.A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjectsDiabetes52(5),1280-1283(2003)
Parton, L.E., Ye, C.P., Coppari, R., et al.Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesityNature449(7159),228-232(2007)
Zhang, C.Y., Parton, L.E., Ye, C.P., et al.Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity-and high glucose-induced ß cell dysfunction in isolated pancreatic isletsCell Metab.3(6),417-427(2006)
Kim, B.C., Kim, H.G., Lee, S.A., et al.Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathwayBiochem. Pharmacol.70(9),1398-1407(2005)
