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Schisandrol B

Cat. No.:YN280134

  • CAS No. :58546-54-6

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    • 生物活性
    • 参考文献
    • 产品名称: Schisandrol B
      CAS No.: 58546-54-6
      Chemical Name: (6S,7S,13aR)-5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol
      Synonyms:五味子醇乙; Gomisin-A; TJN-101; Wuweizi alcohol-B
      分子量:416.46
      分子式:C₂₃H₂₈O₇
      SMILES:O[C@@]([C@@H](C)C1)(C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Schisandrol B (Gomisin-A;TJN-101;Wuweizi alcohol-B) 是肝保护传统中药华中五味子的主要活性成分。
      IC50和靶点:
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    • Taqguchi, H., and Ikeya, Y.The constituents of Schizandra chinensis BAILL. I. The structures of gomisin A, B and CChem. Pharm. Bull.23(12),3296-3298(1975)

      Zeng, H., Jiang, Y., Chen, P., et al.Schisandrol B protects against cholestatic liver injury through pregnane X receptorsBr. J. Pharmacol.174(8),672-688(2017)

      Li, X., Sun, J., Fan, X., et al.Schisandrol B promotes liver regeneration after partial hepatectomy in miceEur. J. Pharmacol.818,96-102(2018)

      Jiang, Y.-m., Wang, Y., Tan, H.-s., et al.Schisandrol B protects against acetaminopheninduced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathwayActa Pharmacol. Sin.37(3),382-389(2016)

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