Cytochalasin E
Cat. No.：YN280156
CAS No. ：36011-19-5
| 产品名称: | Cytochalasin E |
| CAS No.: | 36011-19-5 |
| Chemical Name: | (1E,4S,6R,7E,11aS,14S,14aS,15S,15aR,16aS,16bS)-3,13,14,14a,15,15a,16a,16b-octahydro-6-hydroxy-4,6,15,15a-tetramethyl-14-(phenylmethyl)-[1,3]dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione |
| Synonyms: | |
| 分子量: | 495.56 |
| 分子式: | C₂₈H₃₃NO₇ |
| SMILES: | O=C1[C@]2(O3)[C@]([C@@H]([C@](O4)(C)[C@@H]4[C@]2([H])/C=C/C[C@@H](C([C@](C)(O)/C=C/OC3=O)=O)C)C)([H])[C@H](CC5=CC=CC=C5)N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cytochalasin E 是一种含有曲霉衍生真菌代谢产物的环氧化物，抑制血管生成和肿瘤生长，Cytochalasin E 是一种有效的肌动蛋白解聚剂，能结合肌动蛋白丝的倒刺端并盖住，以防止肌动蛋白伸长。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Brenner, S.L., and Korn, E.D.The effects of cytochalasins on actin polymerization and actin ATPase provide insights into the mechanism of polymerizationJ. Biol. Chem.255(3),841-844(1980)
Lin, D.C., Tobin, K.D., Grumet, M., et al.Cytochalasins inhibit nuclei-induced actin polymerization by blocking filament elongationJ. Cell Biol.84(2),455-460(1980)
Ostlund, R.E., Jr., Leung, J.T., and Hajek, S.V.Regulation of microtubule assembly in cultured fibroblastsJ. Cell Biol.85(2),386-391(1980)
Pinder, J.C., and Gratzer, W.B.Structural and dynamic states of actin in the erythrocyteJ. Cell Biol.96(3),768-775(1983)
Flaumenhaft, R., Dilks, J.R., Rozenvayn, N., et al.The actin cytoskeleton differentially regulates platelet α-granule and dense-granule secretionBlood105(10),3879-3887(2005)
Taheri-Talesh, N., Horio, T., Araujo-Bazán, L., et al.The tip growth apparatus of Aspergillus nidulansMol. Biol. Cell19(4),1439-1449(2008)
dos Santos, T., Varela, J., Lynch, I., et al.Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell linesPLoS One6(9),1-10(2011)
Nightingale, T.D., White, I.J., Doyle, E.L., et al.Actomyosin II contractility expels von Willebrand factor from Weibel-Palade bodies during exocytosisJ. Cell Biol.194(4),613-629(2011)
Udagawa, T., Yuan, J., Panigrahy, D., et al.Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growthJ. Pharmacol. Exp. Ther.294(2),421-427(2000)
Kletzien, R.F., Perdue, J.F., and Springer, A.Cytochalasin A and B. Inhibition of sugar uptake in cultured cellsJ. Biol. Chem.247(9),2964-2966(1972)
Griffin, J.F., Rampal, A.L., and Jung, C.Y.Inhibition of glucose transport in human erythrocytes by cytochalasins: A model based on diffraction studiesProc. Natl. Acad. Sci. USA79(12),3759-3763(1982)
Lombardo, Y.B., Drago, S., Chicco, A., et al.Long-term administration of a sucrose-rich diet to normal rats: Relationship between metabolic and hormonal profiles and morphological changes in the endocrine pancreasMetabolism45(12),1527-1532(1996)
