Alphitolic acid
Cat. No.：YN280166
| 产品名称: | Alphitolic acid |
| CAS No.: | 1268356-17-7 |
| Chemical Name: | 4-(methyl-d3)-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-5-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide-2,3,6-d3 |
| Synonyms: | AMN107-d |
| 分子量: | 535.6 |
| 分子式: | C28H16D6F3N7O |
| SMILES: | O=C(NC1=CC(N2C=C(C)N=C2)=CC(C(F)(F)F)=C1)C3=C([2H])C(NC4=NC(C5=CC=CN=C5)=CC=N4)=C(C([2H])([2H])[2H])C([2H])=C3[2H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nilotinib-d6是 Nilotinib 的一种氘代化合物。Nilotinib 是一种口服的Bcr-Abl酪氨酸激酶抑制剂，具有抗肿瘤活性。 |
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O'Hare, T., Walters, D.K., Stoffregen, E.P., et al.In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutantsCancer Res.65(11),4500-4505(2005)
La Barbera, L., Vedele, F., Nobili, A., et al.Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer's DiseaseProg. Neurobiol.202,102031(2021)
Iyoda, M., Shibata, T., Hirai, Y., et al.Nilotinib attenuates renal injury and prolongs survival in chronic kidney diseaseJ. Am. Soc. Nephrol.22(8),1486-1496(2011)
