BC1618
Cat. No.：YN280173
CAS No. ：2222094-18-8
| 产品名称: | BC1618 |
| CAS No.: | 2222094-18-8 |
| Chemical Name: | 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-2-propanol |
| Synonyms: | |
| 分子量: | 415.5 |
| 分子式: | C24H24F3NO2 |
| SMILES: | FC(F)(C1=CC=C(C=C1)OCC(CN(CC2=CC=CC=C2)CC3=CC=CC=C3)O)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BC1618，是具有口服活性的Fbxo48抑制剂，可刺激Ampk信号 (阻止激活的 pAmpkα 被 Fbxo48 介导的蛋白酶体降解)。BC1618 促进线粒体分裂、促进自噬，提高肝脏胰岛素的敏感性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Liu, Y., Jurczak, M.J., Lear, T.B., et al.A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistanceNat. Chem. Biol.17(3),298-306(2021)
