Poloppin
Cat. No.：YN280178
| 产品名称: | Poloppin |
| CAS No.: | 683808-78-8 |
| Chemical Name: | 5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrole-2-propanoic acid |
| Synonyms: | |
| 分子量: | 438.2378496 |
| 分子式: | C20H15BrF3NO2 |
| SMILES: | OC(CCC1=CC=C(C2=CC=C(Br)C=C2)N1C3=C(C(F)(F)F)C=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Poloppin 是一种有效的细胞渗透抑制剂，可抑制有丝分裂的 polo 样激酶 (PLK) (IC50=26.9 μM)，并可通过Polo-box 结构域 (PBD) 阻止蛋白之间的相互作用 (Kd= 29.5 μM)。Poloppin 选择性地杀死表达突变 KRAS 的细胞，增强有丝分裂中的死亡。Poloppin 可用作 KRAS 突变型癌症的研究，可作为单一试剂，或与 c-MET 抑制剂联合使用。 |
| IC50和靶点: | |
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Narvaez, A.J., Ber, S., Crooks, A., et al.Modulating protein-protein interactions of the mitotic polo-like kinases to target mutant KRASCell Chem. Biol.24(8),1017-1028(2017)
