Divalproex (sodium salt)
Cat. No.：YN280179
| 产品名称: | Divalproex (sodium salt) |
| CAS No.: | 76584-70-8 |
| Chemical Name: | 2-propyl-pentanoic acid, sodium salt (2:1) |
| Synonyms: | VPA (sodium |
| 分子量: | 155.7 |
| 分子式: | C8H16O2 • 1/2Na |
| SMILES: | CCCC(CCC)C(O)=O.CCCC(CCC)C(O)=O.[Na] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Valproic acid (VPA) sodium (2:1) 是一种具有口服活性的HDAC抑制剂，IC50值为 0.5-2 mM，抑制HDAC1的活性，(IC50，400 μM)，同时可诱导HDAC2的降解。Valproic acid sodium (2:1) 激活Notch1信号并抑制小细胞肺癌 (SCLC) 细胞的增殖。Valproic acid sodium (2:1) 可用于癫痫、双相情感障碍、代谢疾病、HIV 感染和偏头痛等的研究。 |
| IC50和靶点: | [{name:"HDAC1:400 μM (IC50)"},{name: "HDAC:0.5-2 mM (IC50)'}, 'HDAC2'] |
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| Solvent & Solubility: |
McGraw, D.Therapeutic drug monitoring with valproate–why product selection is an important factorMental Health Clinician4(1),31-34(2014)
