Ataluren
Cat. No.：YN280181
CAS No. ：775304-57-9
| 产品名称: | Ataluren |
| CAS No.: | 775304-57-9 |
| Chemical Name: | 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-benzoic acid |
| Synonyms: | 阿塔鲁伦; PTC124 |
| 分子量: | 284.3 |
| 分子式: | C15H9FN2O3 |
| SMILES: | OC(C1=CC=CC(C2=NOC(C3=C(F)C=CC=C3)=N2)=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ataluren (PTC124) 是可口服的CFTR-G542X无义等位基因抑制剂。 |
| IC50和靶点: | |
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Finkel, R.S.Read-through strategies for suppression of nonsense mutations in Duchenne/Becker muscular dystrophy: Aminoglycosides and ataluren (PTC124)J. Child Neurol.25(9),1158-1164(2010)
Du, M., Liu, X., Welch, E.M., et al.PTC124 is an orally bioavailable compound that promotes suppression of the human CFTR-G542X nonsense allele in a CF mouse modelProc. Natl. Acad. Sci. USA105(6),2064-2069(2008)
Auld, D.S., Thorne, N., Maguire, W.F., et al.Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppressionProc. Natl. Acad. Sci. USA106(9),3585-3590(2009)
Wilschanski, M., Miller, L.L., Shoseyov, D., et al.Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosisEur. Respir .J.38(1),59-69(2011)
McElroy, S.P., Nomura, T., Torrie, L.S., et al.A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assaysPLoS Biol.11(6),1-8(2013)
