CZC-25146 hydrochloride
Cat. No.：YN280188
| 产品名称: | CZC-25146 hydrochloride |
| CAS No.: | 1330003-04-7 |
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| 分子量: | 525.0 |
| 分子式: | C22H26ClFN6O4S |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CZC-25146 hydrochloride 是一种有效且具有口服活性的LRRK2抑制剂，对野生型LRRK2和突变型LRRK2G2019S 的IC50分别为 4.76 nM 和 6.87 nM，也抑制激酶 PLK4、GAK、TNK1、CAMKK2 和 PIP4K2C。CZC-25146 hydrochloride 能在体外抑制突变LRRK2诱导的神经元损伤。CZC-25146 hydrochloride 在小鼠体内表现出相对较好的药代动力学特性。CZC-25146 hydrochloride 还能增加正 |
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