ML230
Cat. No.：YN360266
| 产品名称: | ML230 |
| CAS No.: | 1776055-05-0 |
| Chemical Name: | 3-furanyl[4-[5-(2-furanyl)-2-phenylpyrazolo[1,5-a]pyrimidin-7-yl]-1-piperazinyl]-methanone |
| Synonyms: | CID44640177; SID 88095709 |
| 分子量: | 439.47 |
| 分子式: | C₂₅H₂₁N₅O₃ |
| SMILES: | O=C(C1=COC=C1)N2CCN(C3=CC(C4=CC=CO4)=NC5=CC(C6=CC=CC=C6)=NN53)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML230 (CID44640177; SID 88095709) 是一种 ATP 结合转运因亚型ABCG2的选择性抑制剂， 对 ABCG2 的抑制作用是 ABCB1 的 36 倍，EC50值分别为 0.13 μM 和 4.65 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Strouse, J.J., Ivnitski-Steele, I., Khawaja, H.M., et al.A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometryJ. Biomol. Screen.18(1),26-38(2013)
Ricci, J.W., Lovato, D.M., Severns, V., et al.Novel ABCG2 antagonists reverse topotecan-mediated chemotherapeutic resistance in ovarian carcinoma xenograftsMol. Cancer Ther.15(12),2853-2862(2016)
