PCI 29732
Cat. No.：YN360647
CAS No. ：330786-25-9
| 产品名称: | PCI 29732 |
| CAS No.: | 330786-25-9 |
| Chemical Name: | 1-cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Synonyms: | PCI29732,PCI-29732 |
| 分子量: | 371.44 |
| 分子式: | C₂₂H₂₁N₅O |
| SMILES: | NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2C5CCCC5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PCI 29732 是一种有效的可逆BTK抑制剂，对 BTK、Lck 和 Lyn 的Kiapp值分别为 8.2、4.6 和 2.5 nM。PCI 29732 对另一种 Tec 家族激酶 Itk 仅有适度的抑制活性。PCI 29732 通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。 |
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Pan, Z., Scheerens, H., Li, S.J., et al.Discovery of selective irreversible inhibitors for Bruton's tyrosine kinaseChemMedChem2(1),58-61(2007)
Ge, C., Wang, F., Ciu, C., et al.PCI29732, a Bruton's tyrosine kinase inhibitor, enhanced the efficacy of conventional chemotherapeutic agents in ABCG2-overexpressing cancer cellsCell. Physiol. Biochem.48(6),2302-2317(2018)
