CHMFL-BMX-078
Cat. No.：YN440028
CAS No. ：1808288-51-8
规格
价格(RMB)
库存
| 产品名称: | CHMFL-BMX-078 |
| CAS No.: | 1808288-51-8 |
| Chemical Name: | 4-(methylamino)-2-[[4-methyl-3-[(1-oxo-2-propen-1-yl)amino]phenyl]amino]-N-[2-methyl-5-[(3,4,5-trimethoxybenzoyl)amino]phenyl]-5-pyrimidinecarboxamide |
| Synonyms: | CHMFL-BMX 078 |
| 分子量: | 625.67 |
| 分子式: | C₃₃H₃₅N₇O₆ |
| SMILES: | O=C(C1=CN=C(NC2=CC=C(C)C(NC(C=C)=O)=C2)N=C1NC)NC3=CC(NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)=CC=C3C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CHMFL-BMX-078是高效的，选择性的，不可逆的，类型IIBMX激酶抑制剂，IC50值为11 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Liang, X., Lv, F., Wang, B., et al.Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a highly potent and selective type II irreversible bone marrow kinase in the X chromosome (BMX) kinase inhibitorJ. Med. Chem.60(5),1793-1816(2017)
Jiang, S., Jiang, T., Huang, H., et al.CHMFL-BMX-078, a BMX inhibitor, overcomes the resistance of melanoma to vemurafenib via inhibiting AKT pathwayChem. Biol. Interact.351,109747(2022)
