Tubercidin
Cat. No.：YN250013
CAS No. ：69-33-0
| 产品名称: | Tubercidin |
| CAS No.: | 69-33-0 |
| Chemical Name: | 7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Synonyms: | 结核菌素; 7-Deazaadenosine |
| 分子量: | 266.25 |
| 分子式: | C₁₁H₁₄N₄O₄ |
| SMILES: | NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)C=C2)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tubercidin (7-Deazaadenosine) 是一种从Streptomyces tubercidicus获得的抗生素，抑制粪链球菌 (8043) 生长的IC50值为 0.02 μM。Tubercidin 通过结合DNA或RNA抑制聚合酶，从而抑制 DNA 复制，RNA 和蛋白质合成。Tubercidin 是腺苷磷酸化酶的弱抑制剂，并干扰腺苷和 AMP 的磷酸化。Tubercidin 具有抗病毒活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bloch, A., Leonard, R.J., and Nichol, C.A.On the mode of action of 7-deaza-adenosine (tubercidin)Biochim. Biophys. Acta138(1),10-25(1967)
Biabani, M.F., Gunasekera, S.P., Longley, R.E., et al.Tubercidin, a cytotoxic agent from the marine sponge Caulospongia biflabellataPharm. Biol.40(4),302-303(2002)
Schultz, D.C., Johnson, R.M., Ayyanathan, K., et al.Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2Nature604(7904),134-140(2022)
el Kouni, M.H., Diop, D., O'Shea, P., et al.Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasisAntimicrob. Agents Chemother.33(6),824-827(1989)
