Aprepitant
Cat. No.：YN250027
CAS No. ：170729-80-3
| 产品名称: | Aprepitant |
| CAS No.: | 170729-80-3 |
| Chemical Name: | 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one |
| Synonyms: | 阿瑞匹坦; MK-0869; MK-869; L-754030 |
| 分子量: | 534.43 |
| 分子式: | C₂₃H₂₁F₇N₄O₃ |
| SMILES: | O=C1NC(CN2[C@H]([C@@H](O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)OCC2)C4=CC=C(F)C=C4)=NN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aprepitant (MK-0869) 是选择性和高亲和力的神经激肽1受体拮抗剂，Kd值为86 pM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bissantz, C., Bohnert, C., Hoffmann, T., et al.Identification of a crucial amino acid in the helix position 6.51 of human tachykinin neurokinin 1 and 3 receptors contributing to the insurmountable mode of antagonism by dual NK1/NK3 antagonistsJ. Med. Chem.55(11),5061-5076(2012)
Finke, P.E., Meurer, L.C., Levorse, D.A., et al.Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SARBioorg. Med. Chem. Lett.16(17),4497-4503(2006)
Meurer, L.C., Finke, P.E., Owens, K.A., et al.Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivativesBioorg. Med. Chem. Lett.16(17),4504-4511(2006)
